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Late recurrences of Sydenham's chorea are not associated with anti- basal ganglia antibodies
journal contribution
posted on 2023-06-08, 13:56 authored by Neil Harrison, A Church, A Nisbet, P Rudge, G GiovannoniAnti-basal ganglia antibodies (ABGA) have been associated with 100% of acute cases and 69% of persistent cases of Sydenham’s chorea. We describe two cases of late recurrences of Sydenham’s chorea with absence of ABGA. Both patients had several childhood episodes of Sydenham’s chorea. MRI imaging of the basal ganglia and exhaustive investigations for other causes of chorea were normal or negative. The absence of ABGA may be evidence against an autoimmune pathology in late and some persistent recurrences. We suggest the likely pathophysiology to be dopamine hypersensitivity of chronically damaged basal ganglia neurones possibly following induction of an autoimmune antibody response in childhood
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Publication status
- Published
Journal
Journal of Neurology, Neurosurgery and PsychiatryISSN
0022-3050Publisher
BMJ Publishing GroupExternal DOI
Issue
10Volume
75Page range
1478-1479Department affiliated with
- Clinical and Experimental Medicine Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-27Usage metrics
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