Adipokinetic hormone and the immune responses of locusts to infection

Goldsworthy, G J, Opoku-Ware, K and Mullen, L M (2005) Adipokinetic hormone and the immune responses of locusts to infection. Annals of the New York Academy of Sciences, 1040. pp. 106-113. ISSN 0077-8923

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Injections of Bacillus, or of blastospores from the entomopathogenic fungus, Metarhizium anisopliae, activate the prophenoloxidase (PPO) cascade, and coinjection of adipokinetic hormone-I (AKH) enhances and prolongs these responses. When injected concurrently with an immunizing dose of live bacteria, AKH suppresses the appearance of antimicrobial activity and, after a short delay, increases the growth of bacteria within the hemocoel. Injections of live Escherichia coli or Pseudomonas aeruginosa into locusts fail to activate PPO in the hemolymph, even when coinjected with AKH. The coinjection of bacteria and hormone is rarely lethal to the locust. However, if locusts are injected with AKH when they are infected with Metarhizium, they die more rapidly than if no AKH is administered.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: Q Science > QR Microbiology > QR0180 Immunology
Depositing User: Lisa Mullen
Date Deposited: 18 Jan 2013 11:50
Last Modified: 05 Oct 2017 18:27
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