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A high-throughput time-resolved mini-silicon photomultiplier with embedded fluorescence lifetime estimation in 0.13um CMOS

journal contribution
posted on 2023-06-08, 14:14 authored by David Tyndall, Bruce R Rae, David Day-Uei Li, Jochen Arlt, Abigail Johnstone, Justin A Richardson, Robert K Henderson
We describe a miniaturized, high-throughput, time-resolved fluorescence lifetime sensor implemented in a 0.13 um CMOS process, combining single photon detection, mul- tiple channel timing and embedded pre-processing of fluorescence lifetime estimations on a single device. Detection is achieved using an array of single photon avalanche diodes (SPADs) arranged in a digital silicon photomultiplier (SiPM) architecture with 400 ps output pulses and a 10% fill-factor. An array of time-to-digital converters (TDCs) with ? ?55 ps resolution records up to 8 photon events during each excitation period. Data from the TDC array is then processed using a centre-of-mass method (CMM) pre-cal- culation to produce fluorescence lifetime estimations in real-time. The sensor is believed to be the first reported implementation of embedded fluorescence lifetime estimation. The system is demon- strated in a practical laboratory environment with measurements of a variety of fluorescent dyes with different single exponential lifetimes, successfully showing the sensor’s ability to overcome the classic pile-up limitation of time-correlated single photon counting (TCSPC) by over an order of magnitude.

History

Publication status

  • Published

Journal

IEEE Transactions on Biomedical Circuits and Systems

ISSN

1932-4545

Publisher

Institute of Electrical and Electronics Engineers (IEEE)

Issue

6

Volume

6

Page range

562-570

Department affiliated with

  • Engineering and Design Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-01-17

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