Tyndall, David, Rae, Bruce R, Li, David Day-Uei, Arlt, Jochen, Johnstone, Abigail, Richardson, Justin A and Henderson, Robert K (2012) A high-throughput time-resolved mini-silicon photomultiplier with embedded fluorescence lifetime estimation in 0.13um CMOS. IEEE Transactions on Biomedical Circuits and Systems, 6 (6). pp. 562-570. ISSN 1932-4545

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Abstract

We describe a miniaturized, high-throughput, time-resolved fluorescence lifetime sensor implemented in a 0.13 um CMOS process, combining single photon detection, mul- tiple channel timing and embedded pre-processing of fluorescence lifetime estimations on a single device. Detection is achieved using an array of single photon avalanche diodes (SPADs) arranged in a digital silicon photomultiplier (SiPM) architecture with 400 ps output pulses and a 10% fill-factor. An array of time-to-digital converters (TDCs) with  55 ps resolution records up to 8 photon events during each excitation period. Data from the TDC array is then processed using a centre-of-mass method (CMM) pre-cal- culation to produce fluorescence lifetime estimations in real-time. The sensor is believed to be the first reported implementation of embedded fluorescence lifetime estimation. The system is demon- strated in a practical laboratory environment with measurements of a variety of fluorescent dyes with different single exponential lifetimes, successfully showing the sensor’s ability to overcome the classic pile-up limitation of time-correlated single photon counting (TCSPC) by over an order of magnitude.

Item Type:	Article
Schools and Departments:	School of Engineering and Informatics > Engineering and Design
Subjects:	Q Science > QA Mathematics > QA0273 Probabilities. Mathematical statistics Q Science > QC Physics > QC0350 Optics. Light > QC0450 Spectroscopy Q Science > QD Chemistry > QD0071 Analytical chemistry T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK0275 Electric standards and measurements T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK7800 Electronics > TK8300 Photoelectronic devices (General)
Related URLs:	Publisher
Depositing User:	David Day-Uei Li
Date Deposited:	17 Jan 2013 11:30
Last Modified:	08 Mar 2017 07:29
URI:	http://srodev.sussex.ac.uk/id/eprint/43481

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