Intersex in Scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption

Ciocan, Corina M, Cubero-Leon, Elena, Peck, Mika R, Langston, William J, Pope, Nick, Minier, Christophe and Rotchell, Jeanette M (2013) Intersex in Scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption. Environmental Science and Technology, 46 (23). pp. 12936-12942. ISSN 0013-936X

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Abstract

Intersex, the appearance of female characteristics in male gonads, has been identified in a wide range of aquatic species worldwide, yet the underpinning molecular etiology remains uncharacterized. The presence of intersex has been shown to be a widespread phenomenon in bivalve, S. plana, populations from the southwest coast of the U.K., as well as inducible in an experimental exposure regime using endocrine disrupting compounds (EDCs). Herein, we use the suppressive subtractive hybridization approach to isolate differentially expressed transcripts in S. plana males exhibiting intersex. Transcripts involved in cell signaling, cell cycle control, energy production/metabolism, microtubule assembly, and sperm physiology are all highlighted as differentially expressed in intersex male clams. These provide both an insight into the molecular mechanisms of action involved in the development of intersex, as well as facilitating potential molecular-level “early warning” biomarkers of the condition.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Subjects: Q Science
Depositing User: Mika Peck
Date Deposited: 18 Mar 2013 14:25
Last Modified: 18 Mar 2013 14:25
URI: http://srodev.sussex.ac.uk/id/eprint/44065
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