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Gold amides as anticancer drugs: synthesis and activity studies

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posted on 2023-06-08, 14:41 authored by Sonya Newcombe, Mariusz Bobin, Amruta Shrikhande, Chris Gallop, Yannick Pace, Helen Yong, Rebecca Gates, Shuvashri Chaudhuri, Mark Roe, Eva Hoffmann, Eddy Viseux
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.

History

Publication status

  • Published

File Version

  • Published version

Journal

Organic and Biomolecular Chemistry

ISSN

1477-0520

Publisher

Royal Society of Chemistry

Issue

11

Volume

19

Page range

3255-3260

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2013-04-15

First Open Access (FOA) Date

2013-04-15

First Compliant Deposit (FCD) Date

2013-04-15

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