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Dynamic coding for cognitive control in prefrontal cortex

journal contribution
posted on 2023-06-08, 14:42 authored by Mark G Stokes, Makoto Kusunoki, Natasha SigalaNatasha Sigala, Hamed Nili, David Gaffan, John Duncan
Cognitive flexibility is fundamental to adaptive intelligent behavior. Prefrontal cortex has long been associated with flexible cognitive function, but the neurophysiological principles that enable prefrontal cells to adapt their response properties according to context-dependent rules remain poorly understood. Here, we use time-resolved population-level neural pattern analyses to explore how context is encoded and maintained in primate prefrontal cortex and used in flexible decision making. We show that an instruction cue triggers a rapid series of state transitions before settling into a stable low-activity state. The postcue state is differentially tuned according to the current task-relevant rule. During decision making, the response to a choice stimulus is characterized by an initial stimulus-specific population response but evolves to different final decision-related states depending on the current rule. These results demonstrate how neural tuning profiles in prefrontal cortex adapt to accommodate changes in behavioral context. Highly flexible tuning could be mediated via short-term synaptic plasticity.

History

Publication status

  • Published

Journal

Neuron

ISSN

0896-6273

Publisher

Elsevier

Issue

2

Volume

78

Page range

364-375

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-04-17

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