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Tissue-protective cytokines: structure and evolution
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posted on 2023-06-08, 14:49 authored by Pietro Ghezzi, Darrell ConklinCytokines are important mediators of host defense and immunity, and were first identified for their role in immunity to infections. It was then found that some of them are pathogenic mediators in inflammatory diseases and much of the emphasis is now on pro-inflammatory cytokines, also in consideration of the fact that TNF inhibitors became effective drugs in chronic inflammatory diseases. The recent studies on the tissue-protective activities of erythropoietin (EPO) led to the term "tissue-protective cytokine." We discuss here how tissue-protective actions might be common to other cytokines, particularly those of the 4-alpha helical structural superfamily.
History
Publication status
- Published
Journal
Methods in molecular biology (Clifton, N.J.)ISSN
1940-6029Publisher
Humana PressExternal DOI
Issue
982Volume
982Page range
43-58Book title
Tissue-protective cytokines: methods and protocolsSeries
Methods in molecular biologyDepartment affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Editors
Anthony Cermi, Pietro GhezziLegacy Posted Date
2013-04-30Usage metrics
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