A new approach to structural integrity assessment based on axial and radial diffusivities

Wheeler-Kingshott, Claudia A M, Ciccarelli, Olga, Schneider, Torben, Alexander, Daniel C and Cercignani, Mara (2012) A new approach to structural integrity assessment based on axial and radial diffusivities. Functional Neurology, 27 (2). pp. 85-90. ISSN 0393-5264

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This study describes a method for performing diffusivity measures along and across a specific direction, derived from white matter in healthy controls. The diffusion tensor (DT) assigns a principal eigenvector (v₁) and eigenvalue (axial diffusivity, d(ax)) to each voxel. The average of the second and third eigenvalues is the radial diffusivity, d(rad) v₁ may be affected by pathology, therefore when comparing d(ax) and d(rad) in patients one has to consider the direction of the measurement and underlying anatomy. Here we created a representative super-DT dataset, DT(ref), whose eigenvector, v(1,ref), was considered the most likely direction of diffusivity per voxel. We defined the projected axial diffusivity, d(p-ax), as the projection of individual DTs along v(1,ref) and the projected radial diffusivity, d(p-rad), as the average of the projections along the second and third eigenvectors of DT(ref). The projected diffusivities are promising new parameters for studying white matter pathology.

Item Type: Article
Keywords: axial diffusivity; diffusion tensor; DTI; Eigen values; radial diffusivity; template
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine
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Depositing User: Patricia Butler
Date Deposited: 13 May 2013 13:53
Last Modified: 26 Sep 2017 13:11
URI: http://srodev.sussex.ac.uk/id/eprint/44672
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