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A new approach to structural integrity assessment based on axial and radial diffusivities

journal contribution
posted on 2023-06-08, 14:54 authored by Claudia A M Wheeler-Kingshott, Olga Ciccarelli, Torben Schneider, Daniel C Alexander, Mara Cercignani
This study describes a method for performing diffusivity measures along and across a specific direction, derived from white matter in healthy controls. The diffusion tensor (DT) assigns a principal eigenvector (v1) and eigenvalue (axial diffusivity, d(ax)) to each voxel. The average of the second and third eigenvalues is the radial diffusivity, d(rad) v1 may be affected by pathology, therefore when comparing d(ax) and d(rad) in patients one has to consider the direction of the measurement and underlying anatomy. Here we created a representative super-DT dataset, DT(ref), whose eigenvector, v(1,ref), was considered the most likely direction of diffusivity per voxel. We defined the projected axial diffusivity, d(p-ax), as the projection of individual DTs along v(1,ref) and the projected radial diffusivity, d(p-rad), as the average of the projections along the second and third eigenvectors of DT(ref). The projected diffusivities are promising new parameters for studying white matter pathology.

History

Publication status

  • Published

Journal

Functional Neurology

ISSN

0393-5264

Publisher

CIC Edizione Internazionale

Issue

2

Volume

27

Page range

85-90

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-05-13

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