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Estimating the number of double-strand breaks formed during meiosis from partial observation

journal contribution
posted on 2023-06-08, 15:02 authored by Hiroshi Toyoizumi, Hideo Tsubouchi
Analyzing the basic mechanism of DNA double-strand breaks (DSB) formation during meiosis is important for understanding sexual reproduction and genetic diversity. The location and amount of meiotic DSBs can be examined by using a common molecular biological technique called Southern blotting, but only a subset of the total DSBs can be observed; only DSB fragments still carrying the region recognized by a Southern blot probe are detected. With the assumption that DSB formation follows a nonhomogeneous Poisson process, we propose two estimators of the total number of DSBs on a chromosome: (1) an estimator based on the Nelson-Aalen estimator, and (2) an estimator based on a record value process. Further, we compared their asymptotic accuracy.

History

Publication status

  • Published

Journal

Journal of Computational Biology

ISSN

1066-5277

Publisher

Mary Ann Liebert

Issue

12

Volume

19

Page range

1277-1283

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-05-23

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