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Dynamics of HIV type 1 recombination following superinfection

journal contribution
posted on 2023-06-08, 15:29 authored by Fransje A Koning, Anjna Badhan, Simon Shaw, Martin Fisher, Jean L Mbisa, Patricia A Cane
There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with "wild-type" subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.

History

Publication status

  • Published

Journal

AIDS Research and Human Retroviruses

ISSN

0889-2229

Publisher

Mary Ann Liebert

Issue

6

Volume

29

Page range

963-970

Department affiliated with

  • BSMS Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-08-19

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