File(s) not publicly available
Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe
journal contribution
posted on 2023-06-08, 15:30 authored by Andrea De Luca, Martin Fisher, The SHERE CollaborationHIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.
History
Publication status
- Published
Journal
The Journal of infectious diseasesISSN
1537-6613Publisher
Oxford JournalsExternal DOI
Issue
8Volume
207Page range
1216-1220Department affiliated with
- BSMS Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2013-08-19Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC