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Impact of HIV-1 subtype on CD4 count at HIV seroconversion, rate of decline, and viral load set point in European seroconverter cohorts

journal contribution
posted on 2023-06-08, 15:30 authored by Giota Touloumi, Nikos Pantazis, Deenan Pillay, Dimitrios Paraskevis, Marie-Laure Chaix, Heiner C Bucher, Claudia Kücherer, Robert Zangerle, Anne-Marte Bakken Kran, Kholoud Porter, Martin Fisher, The CASCADE collaboration in EuroCoord
BACKGROUND Human immunodeficiency virus type 1 (HIV-1) subtype may influence disease progression. We compared CD4 lymphocyte cell count levels at seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 subtypes. METHODS We used data from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration, restricted to those infected since 1996, aged =15 years, and applied mixed effects models for CD4 cell count decline and median regression for viral load set point (mean level 6-24 months from seroconversion). RESULTS The analysis included 3364 seroconverters with known HIV-1 subtypes. Compared with subtype B, CD4 at seroconversion was significantly higher for subtype CRF01 and lower for subtype C. Subsequent CD4 decline was significantly slower for subtypes A and CRF02 and marginally slower for subtype C compared with B. Mean CD4 loss at 2 years of seroconversion for white men exposed through sex between men, aged 30-39 years, having seroconverted since 2006, enrolled within 6 months of seroconversion, and without acute infection was 88, 142, 100, 130, 103, and 167 cells/µL for subtypes A, B, C, CRF01_AE, CRF02_AG, and G, respectively. In adjusted analysis, median viral load set point and time to clinical AIDS/death did not differ significantly by subtype, although all subtypes, except C, tended to have lower levels compared with B. CONCLUSIONS HIV-1 subtype significantly influences seroconversion CD4 cell levels and decline rates but not viral load set point. These findings may be helpful to HIV-positive individuals and their attending physicians in understanding disease progression.

History

Publication status

  • Published

Journal

Clinical Infectious Diseases

ISSN

1537-6591

Publisher

Oxford University Press

Issue

6

Volume

56

Page range

888-897

Department affiliated with

  • BSMS Publications

Notes

Martin Fisher is not listed on the main author citation list but forms part of the CASCADE collaboration in EuroCoord

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-08-12

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