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Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames
journal contribution
posted on 2023-06-08, 15:32 authored by Emile G Magny, Jose Pueyo-Marques, Frances PearlFrances Pearl, Miguel Angel Cespedes, Jeremy NivenJeremy Niven, Sarah Bishop, Juan Pablo CousoSmall Open Reading Frames (smORFs) are short DNA sequences able to encode small peptides of less than 100 amino acids. Study of these elements has been neglected despite thousands existing in our genomes. We and others showed previously that peptides as short as 11 amino acids are translated and provide essential functions during insect development. Here, we describe two peptides of less than 30 amino acids regulating calcium transport, and hence influencing regular muscle contraction, in the Drosophila heart. These peptides seem conserved for more than 550 million years in a range of species from flies to humans, where they have been implicated in cardiac pathologies. Such conservation suggests that the mechanisms for heart regulation are ancient and that smORFs may be a fundamental genome component that should be studied systematically.
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Publication status
- Published
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ScienceISSN
0036-8075Publisher
American Association for the Advancement of SciencePublisher URL
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341Page range
1116-1120Department affiliated with
- Biology and Environmental Science Publications
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- No
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- Yes
Legacy Posted Date
2013-08-27Usage metrics
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