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New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules

journal contribution
posted on 2023-06-08, 15:52 authored by Valentina Oliveri, Antonino Puglisi, Maurizio Viale, Cinzia Aiello, Carmelo Sgarlata, Graziella Vecchio, James Clarke, John Milton, John SpencerJohn Spencer
Recent investigations have rekindled interest in 8-hydroxyquinolines as therapeutic agents for cancer, Alzheimer’s disease, and other neurodegenerative disorders. Three new ß-cyclodextrin conjugates of 8-hydroxyquinolines and their copper(II) and zinc(II) complexes have been synthesized and characterized spectroscopically. In addition to improving aqueous solubility, due to the presence of the cyclodextrin moiety, the hybrid systems have interesting characteristics including antioxidant activity, and their copper(II) complexes are efficient superoxide dismutase (SOD) mimics. The ligands and their copper(II) complexes show low cytotoxicity, attributed to the presence of the cyclodextrin moiety. These compounds have potential as therapeutic agents in diseases related both to metal dyshomeostasis and oxidative stress.

History

Publication status

  • Published

Journal

Chemistry - A European Journal

ISSN

0947-6539

Publisher

Wiley-VCH Verlag

Issue

41

Volume

19

Page range

13946-13955

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-09-19

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