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New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules
journal contribution
posted on 2023-06-08, 15:52 authored by Valentina Oliveri, Antonino Puglisi, Maurizio Viale, Cinzia Aiello, Carmelo Sgarlata, Graziella Vecchio, James Clarke, John Milton, John SpencerJohn SpencerRecent investigations have rekindled interest in 8-hydroxyquinolines as therapeutic agents for cancer, Alzheimer’s disease, and other neurodegenerative disorders. Three new ß-cyclodextrin conjugates of 8-hydroxyquinolines and their copper(II) and zinc(II) complexes have been synthesized and characterized spectroscopically. In addition to improving aqueous solubility, due to the presence of the cyclodextrin moiety, the hybrid systems have interesting characteristics including antioxidant activity, and their copper(II) complexes are efficient superoxide dismutase (SOD) mimics. The ligands and their copper(II) complexes show low cytotoxicity, attributed to the presence of the cyclodextrin moiety. These compounds have potential as therapeutic agents in diseases related both to metal dyshomeostasis and oxidative stress.
History
Publication status
- Published
Journal
Chemistry - A European JournalISSN
0947-6539Publisher
Wiley-VCH VerlagExternal DOI
Issue
41Volume
19Page range
13946-13955Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2013-09-19Usage metrics
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