New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules

Oliveri, Valentina, Puglisi, Antonino, Viale, Maurizio, Aiello, Cinzia, Sgarlata, Carmelo, Vecchio, Graziella, Clarke, James, Milton, John and Spencer, John (2013) New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules. Chemistry - A European Journal, 19 (41). pp. 13946-13955. ISSN 0947-6539

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Abstract

Recent investigations have rekindled interest in 8-hydroxyquinolines as therapeutic agents for cancer, Alzheimer’s disease, and other neurodegenerative disorders. Three new β-cyclodextrin conjugates of 8-hydroxyquinolines and their copper(II) and zinc(II) complexes have been synthesized and characterized spectroscopically. In addition to improving aqueous solubility, due to the presence of the cyclodextrin moiety, the hybrid systems have interesting characteristics including antioxidant activity, and their copper(II) complexes are efficient superoxide dismutase (SOD) mimics. The ligands and their copper(II) complexes show low cytotoxicity, attributed to the presence of the cyclodextrin moiety. These compounds have potential as therapeutic agents in diseases related both to metal dyshomeostasis and oxidative stress.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science
Depositing User: Deeptima Massey
Date Deposited: 19 Sep 2013 14:20
Last Modified: 09 Jul 2014 13:50
URI: http://srodev.sussex.ac.uk/id/eprint/46397
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