Granger causality analysis of fMRI BOLD signals is invariant to hemodynamic convolution but not downsampling

Seth, Anil, Chorley, Paul and Barnett, Lionel (2013) Granger causality analysis of fMRI BOLD signals is invariant to hemodynamic convolution but not downsampling. NeuroImage, 65. pp. 540-555. ISSN 1053-8119

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Granger causality is a method for identifying directed functional connectivity based on time series analysis of precedence and predictability. The method has been applied widely in neuroscience, however its application to functional MRI data has been particularly controversial, largely because of the suspicion that Granger causal inferences might be easily confounded by inter-regional differences in the hemodynamic response function. Here, we show both theoretically and in a range of simulations, that Granger causal inferences are in fact robust to a wide variety of changes in hemodynamic response properties, including notably their time-to-peak. However, when these changes are accompanied by severe downsampling, and/or exces- sive measurement noise, as is typical for current fMRI data, incorrect inferences can still be drawn. Our results have important implications for the ongoing debate about lag-based analyses of functional connectivity. Our methods, which include detailed spiking neuronal models coupled to biophysically realistic hemodynamic observation models, provide an important ‘analysis-agnostic’ platform for evaluating functional and effective connectivity methods.

Item Type: Article
Schools and Departments: School of Engineering and Informatics > Informatics
Subjects: Q Science > QA Mathematics > QA0273 Probabilities. Mathematical statistics
Q Science > QA Mathematics > QA0075 Electronic computers. Computer science
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Anil Seth
Date Deposited: 20 Oct 2013 09:37
Last Modified: 13 Mar 2017 10:53

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