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Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks

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posted on 2023-06-08, 16:11 authored by Andrew D Burrows, Monika Jurcic, Luke L Keenan, Rebecca A Lane, Mary F Mahon, Mark R Warren, Harriot Nowell, Michael Paradowski, John SpencerJohn Spencer
A series of new zinc-based metal–organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.

History

Publication status

  • Published

File Version

  • Published version

Journal

Chemical Communications

ISSN

1359-7345

Publisher

Royal Society of Chemistry

Volume

49

Page range

11260-11262

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2013-10-23

First Open Access (FOA) Date

2014-10-17

First Compliant Deposit (FCD) Date

2014-07-18

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