University of Sussex
Browse

File(s) not publicly available

Increase in transmitted HIV drug resistance among persons undergoing genotypic resistance testing in Ontario, Canada, 2002-09

journal contribution
posted on 2023-06-08, 16:21 authored by Ann N Burchell, Ahmed M Bayoumi, Sean B Rourke, Carol Major, Sandra Gardner, Paul Sandstrom, Anita Rachlis, Darien Taylor, Tony Mazzulli, Mark Fisher, James Brooks, Martin Fisher, The OHTN Cohort Study Research Team
OBJECTIVES To characterize persons undergoing HIV genotypic resistance testing (GRT) while treatment naive and to estimate the prevalence of transmitted HIV drug resistance (TDR) among HIV-positive outpatients in Ontario, Canada. METHODS We analysed data from a multi-site cohort of persons receiving HIV care. Data were obtained from medical chart abstractions, interviews and record linkage with the Public Health Laboratories, Public Health Ontario. The analysis was restricted to 626 treatment-naive persons diagnosed in 2002-09. TDR mutations were identified using the calibrated population resistance tool. We used descriptive statistics and regression methods to characterize treatment-naive GRT test uptake and patterns of TDR. RESULTS Overall, 53.2% (333/626) of participants had baseline GRT. The proportion increased with year of HIV diagnosis from 30.0% in 2002 to 82.6% in 2009 (P?

History

Publication status

  • Published

Journal

Journal of Antimicrobial Chemotherapy

Publisher

Oxford University Press

Issue

11

Volume

67

Page range

2755-2765

Department affiliated with

  • BSMS Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-11-25

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC