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Jarrin, Inma, Pantazis, Nikos, Gill, M John, Geskus, Ronald, Perez-Hoyos, Santiago, Meyer, Laurence, Prins, Maria, Touloumi, Giota, Johnson, Anne, Hamouda, Osamah, de Olalla, Patricia García, Porter, Kholoud, del Amo, Julia, Fisher, Martin and The CASCADE Collaboration in EuroCoord, (2012) Uptake of combination antiretroviral therapy and HIV disease progression according to geographical origin in seroconverters in Europe, Canada, and Australia. Clinical Infectious Diseases, 54 (1). pp. 111-118. ISSN 1058-4838
Full text not available from this repository.Abstract
BACKGROUND
We examined differences by geographical origin (GO) in time from HIV seroconversion (SC) to AIDS, death, and initiation of antiretroviral therapy (cART).
METHODS
Data from HIV seroconverter cohorts in Europe, Australia and Canada (CASCADE) was used; GO was classified as: western countries (WE), North Africa and Middle East (NAME), sub-Saharan Africa (SSA), Latin America (LA), and Asia (ASIA). Differences by GO were assessed using Cox models. Administrative censoring date was 30 June 2008.
RESULTS
Of 16 941 seroconverters, 15 548 were from WE, 158 NAME, 762 SSA, 349 LA, and 124 ASIA. We found no differences by GO in risks of AIDS (P = .99) and death (P = .12), although seroconverters from NAME (adjusted hazard ratio [aHR]: 0.57; 95% CI: 0.33-.94) and SSA (aHR: 0.74; 95% CI: 0.50-1.10) appeared to have lower mortality than WE. Chances of initiating cART differed by GO (P < .001): seroconverters from SSA were more likely to initiate cART than WE (aHR: 1.48; 95% CI: 1.26-1.74), but not after adjustment for CD4 at SC (aHR: 1.11; 95% CI: 0.88-1.40).
CONCLUSIONS
In settings with universal access to healthcare, GO does not play a major role in HIV disease progression.
| Item Type: | Article |
|---|---|
| Additional Information: | Martin Fisher is part of the CASCADE Collaboration in EuroCoord, but is not a named author on the article. |
| Schools and Departments: | Brighton and Sussex Medical School > Brighton and Sussex Medical School |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine > RA0643 Communicable diseases and public health > RA0644 Individual diseases or groups of diseases, A-Z > RA0644.A25 AIDS. HIV infections |
| Related URLs: | |
| Depositing User: | Ellen Thomas |
| Date Deposited: | 13 Dec 2013 14:24 |
| Last Modified: | 23 Dec 2013 12:27 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/47096 |