Memantine affects cognitive flexibility in the Morris water maze

Saab, Bechara J, Luca, Ruxandra M, Yuen, Wing B, Saab, Adam M P and Roder, John C (2011) Memantine affects cognitive flexibility in the Morris water maze. Journal of Alzheimer's Disease, 27 (3). pp. 477-482. ISSN 1387-2877

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Alzheimer's disease (AD) is multi-factorial mental disorder characterized by a copious array of congruent features cumulating in disrupted memory and dysthymia. Though the mechanism remains elusive, the highly unspecific pharmaceutical, memantine, provides modest benefits for patients with moderate-to-severe AD. A greater understanding of how memantine affects cognitive function promises to facilitate the search for better therapeutics. We therefore examined cognitive flexibility of mice following 5 and 10 mg/kg memantine administration using a platform re-location water maze. Strikingly, subjects receiving memantine demonstrated memory impairment relative to controls when re-trained off drug, revealing a novel and unusual disruption of cognitive flexibility.

Item Type: Article
Schools and Departments: School of Business, Management and Economics > Business and Management
Subjects: B Philosophy. Psychology. Religion > BF Psychology > BF0180 Experimental psychology
Depositing User: Ruxandra Luca
Date Deposited: 22 Nov 2013 10:56
Last Modified: 22 Nov 2013 10:56
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