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HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era
journal contribution
posted on 2023-06-08, 16:42 authored by The UK Collaborative HIV Cohort (CHIC) Study Steering Committee, Martin FisherBACKGROUND AND PURPOSE Data describing the incidence and survival of HIV-related central nervous system diseases (CNS-D) in recent years are sparse. METHODS Between 1996 and 2007, adult subjects without previous CNS-D within a large UK cohort were included (n=30,954). CNS-D were HIV encephalopathy (HIVe), progressive multifocal leucoencephalopathy (PML), cerebral toxoplasmosis (TOXO) and cryptococcal meningitis (CRYP). Associations between demographic, clinical and laboratory parameters with incidence and survival of CNS-D were evaluated using Poisson regression analysis and Kaplan-Meier techniques. RESULTS Six hundred and thirteen new CNS-D occurred in 574 subjects (HIVe:187, PML:113, TOXO:184, CRYP:129). Incidence of all CNS-D declined from 13.1 per 1000 PY in 1996/1997 to 1.0 per 1000 PY in 2006/2007 (P=0.0001). Current CD4+ cell count below 200 cells/ul and plasma HIV RNA above 100,000 copies/ml were independently associated with the development of CNS-D. Calendar year 1996/1997, older age, prior AIDS diagnosis and PML diagnosis were significantly associated with shorter survival. CONCLUSIONS An ongoing decline in the incidence of CNS-D has been observed in very recent years. Mortality following such a diagnosis remains high.
History
Publication status
- Published
Journal
European Journal of NeurologyISSN
1351-5101Publisher
WileyExternal DOI
Issue
3Volume
18Page range
527-34Department affiliated with
- BSMS Publications
Notes
Martin Fisher is a member of the UK CHIC writing committee and is named in the article's appendix as one of the authors of this article.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-03-03Usage metrics
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