HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era

The UK Collaborative HIV Cohort (CHIC) Study Steering Committee, and Fisher, Martin (2011) HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era. European Journal of Neurology, 18 (3). pp. 527-34. ISSN 1351-5101

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Data describing the incidence and survival of HIV-related central nervous system diseases (CNS-D) in recent years are sparse.


Between 1996 and 2007, adult subjects without previous CNS-D within a large UK cohort were included (n=30,954). CNS-D were HIV encephalopathy (HIVe), progressive multifocal leucoencephalopathy (PML), cerebral toxoplasmosis (TOXO) and cryptococcal meningitis (CRYP). Associations between demographic, clinical and laboratory parameters with incidence and survival of CNS-D were evaluated using Poisson regression analysis and Kaplan-Meier techniques.


Six hundred and thirteen new CNS-D occurred in 574 subjects (HIVe:187, PML:113, TOXO:184, CRYP:129). Incidence of all CNS-D declined from 13.1 per 1000 PY in 1996/1997 to 1.0 per 1000 PY in 2006/2007 (P=0.0001). Current CD4+ cell count below 200 cells/ul and plasma HIV RNA above 100,000 copies/ml were independently associated with the development of CNS-D. Calendar year 1996/1997, older age, prior AIDS diagnosis and PML diagnosis were significantly associated with shorter survival.


An ongoing decline in the incidence of CNS-D has been observed in very recent years. Mortality following such a diagnosis remains high.

Item Type: Article
Additional Information: Martin Fisher is a member of the UK CHIC writing committee and is named in the article's appendix as one of the authors of this article.
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine > RA0643 Communicable diseases and public health > RA0644 Individual diseases or groups of diseases, A-Z > RA0644.A25 AIDS. HIV infections
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Depositing User: Ellen Thomas
Date Deposited: 03 Mar 2014 14:57
Last Modified: 03 Mar 2014 14:57
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