University of Sussex
Browse

File(s) not publicly available

HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era

journal contribution
posted on 2023-06-08, 16:42 authored by The UK Collaborative HIV Cohort (CHIC) Study Steering Committee, Martin Fisher
BACKGROUND AND PURPOSE Data describing the incidence and survival of HIV-related central nervous system diseases (CNS-D) in recent years are sparse. METHODS Between 1996 and 2007, adult subjects without previous CNS-D within a large UK cohort were included (n=30,954). CNS-D were HIV encephalopathy (HIVe), progressive multifocal leucoencephalopathy (PML), cerebral toxoplasmosis (TOXO) and cryptococcal meningitis (CRYP). Associations between demographic, clinical and laboratory parameters with incidence and survival of CNS-D were evaluated using Poisson regression analysis and Kaplan-Meier techniques. RESULTS Six hundred and thirteen new CNS-D occurred in 574 subjects (HIVe:187, PML:113, TOXO:184, CRYP:129). Incidence of all CNS-D declined from 13.1 per 1000 PY in 1996/1997 to 1.0 per 1000 PY in 2006/2007 (P=0.0001). Current CD4+ cell count below 200 cells/ul and plasma HIV RNA above 100,000 copies/ml were independently associated with the development of CNS-D. Calendar year 1996/1997, older age, prior AIDS diagnosis and PML diagnosis were significantly associated with shorter survival. CONCLUSIONS An ongoing decline in the incidence of CNS-D has been observed in very recent years. Mortality following such a diagnosis remains high.

History

Publication status

  • Published

Journal

European Journal of Neurology

ISSN

1351-5101

Publisher

Wiley

Issue

3

Volume

18

Page range

527-34

Department affiliated with

  • BSMS Publications

Notes

Martin Fisher is a member of the UK CHIC writing committee and is named in the article's appendix as one of the authors of this article.

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-03-03

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC