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Fisher, Martin, Pao, David, Brown, Alison E, Sudarshi, Darshan, Gill, O Noel, Cane, Patricia, Buckton, Andrew J, Parry, John V, Johnson, Anne M, Sabin, Caroline and Pillay, Deenan (2010) Determinants of HIV-1 transmission in men who have sex with men: a combined clinical, epidemiological and phylogenetic approach. AIDS, 24 (11). pp. 1739-1747. ISSN 0269-9370
Full text not available from this repository.Abstract
OBJECTIVES
To identify biological factors associated with HIV transmission in men who have sex with men (MSM).
DESIGN
A longitudinal phylogenetic analysis of HIV-1 from an MSM cohort, incorporating clinical and epidemiological data.
METHODS
Potential individuals were HIV-infected MSM attending a sexual health clinic between 2000 and 2006. Individuals were classified such that they could move from recent to chronic infection categories. HIV-1pol gene sequences were obtained from plasma virus or proviral DNA and clusters estimated by maximum likelihood and conservative genetic distance differences. The single most likely transmitter generating each recent infection was ascertained and risk factors around time of likely transmission explored using Poisson regression modelling.
RESULTS
Out of 1144 HIV-infected MSM, pol sequence data were obtained for 859 (75%); 159 out of 859 (19%) were recently HIV infected at diagnosis. A single most likely transmitter was identified for 41 out of 159 (26%), of which 11 were recently infected (27%) and 30 chronically infected. Factors associated with transmission in multivariable analysis were: younger age {rate ratio per 5 years older 0.68 [95% confidence interval (CI) 0.54-0.86], P=0.0009}, higher viral load [rate ratio per log higher 1.61 (95% CI 1.15-2.25), P=0.005], recent infection [rate ratio 3.88 (95% CI 1.76-8.55), P=0.0008] and recent sexually transmitted disease [rate ratio 5.32 (95% CI 2.51-11.29), P=0.0001]. HAART was highly protective in a univariable model, RR 0.14 (95% CI 0.07-0.27, P=0.0001).
CONCLUSION
Onward transmission of HIV among MSM is significantly associated with recent infection, sexually transmitted diseases and higher viral load, and reduced by effective HAART. The majority of new infections appear to occur from individuals whose infection was undiagnosed at the time of transmission.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Brighton and Sussex Medical School |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine > RA0643 Communicable diseases and public health > RA0644 Individual diseases or groups of diseases, A-Z > RA0644.A25 AIDS. HIV infections |
| Related URLs: | |
| Depositing User: | Ellen Thomas |
| Date Deposited: | 07 Apr 2014 14:28 |
| Last Modified: | 07 Apr 2014 14:28 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/47554 |