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A hallmark of balancing selection is present at the promoter region of interleukin 10

journal contribution
posted on 2023-06-08, 17:09 authored by J N Wilson, K Rockett, B Keating, M Jallow, M Pinder, F Sisay-Joof, Melanie NewportMelanie Newport, D Kwiatkowski
As an anti-inflammatory mediator IL10 is beneficial in certain contexts and deleterious in others. As increased production of IL10 favours protection against inflammatory disease, whereas low production promotes elimination of foreign pathogens by the host, we investigated the possible influence of balancing selection at this locus. We began by resequencing 48 European and 48 African chromosomes across 2.2 kb of the IL10 promoter region, and compared this with four neighbouring gene regions: MK2, IL19, IL20 and IL24. Analysis of nucleotide diversity showed a positive Tajima's D-test for IL10 in Europeans, of borderline statistical significance (1.89, P=0.05). Analysis of F(st) values showed significant population divergence at MK2, IL19, IL20 and IL24 (P<0.01) but not at IL10. Taken together, these findings are consistent with the hypothesis that balancing selection has played a role in the evolution of polymorphisms in the IL10 promoter region.

History

Publication status

  • Published

Journal

Genes and Immunity

ISSN

1466-4879

Publisher

Nature Publishing Group

Issue

8

Volume

7

Page range

680-683

Department affiliated with

  • Primary Care and Public Health Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-05-09

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