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Influence of genetic and environmental factors on the immunogenicity of Hib vaccine in Gambian twins
journal contribution
posted on 2023-06-08, 17:09 authored by Y C Lee, Melanie NewportMelanie Newport, T Goetghebuer, C A Siegrist, H A Weiss, A J Pollard, A Marchant, The MRC Twin Study Group 1The differences in incidence rates of Haemophilus influenzae type b disease and the variation in Hib conjugate vaccine efficacy achieved among different ethnic groups suggest genetic influences on the immune response to Hib vaccine. The serum anti-PRP antibody concentration of 43 monozygotic (MZ) and 147 dizygotic (DZ) twin pairs in the Gambia was measured using a standardised Hib ELISA. Intrapair correlations for MZ and DZ twin pairs were compared and heritability in antibody responses to Hib conjugate vaccine was estimated to be 51% (95% CI: 32-66%), indicating a significant genetic contribution in the response. We conclude that genetic factors may be involved in the variation in immune response to Hib vaccine observed in different populations and may contribute to cases of vaccine failure.
History
Publication status
- Published
Journal
VaccineISSN
0264-410XPublisher
ElsevierExternal DOI
Issue
25Volume
24Page range
5335-5340Department affiliated with
- Primary Care and Public Health Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-05-09Usage metrics
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