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Global distribution of a novel trinucleotide microsatellite polymorphism (ATA)n in intron 8 of the SLC11A1 gene and susceptibility to pulmonary tuberculosis
journal contribution
posted on 2023-06-08, 17:09 authored by A Awomoyi, G Sirugo, Melanie NewportMelanie Newport, S TishkoffWe identified a novel trinucleotide (ATA)n repeat polymorphism in intron 8 of SLC11AI, a candidate gene for susceptibility to tuberculosis (TB) infection. We characterized the frequency of this polymorphism in 485 individuals originating from eight globally diverse human populations and compared the distribution of (ATA)n alleles in 146 adults and in 80 cord blood samples from newborns in the Gambian population. Lastly, we tested for association of this microsatellite with pulmonary TB in 318 TB cases and 146 controls in the Gambian population. We found no significant difference in frequency or distribution of alleles in adult and cord blood samples, and we found no significant association between this marker and pulmonary TB.
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Publication status
- Published
Journal
International Journal of ImmunogeneticsISSN
1744-3121Publisher
WileyExternal DOI
Issue
1Volume
33Page range
11-15Department affiliated with
- Primary Care and Public Health Publications
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- No
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- Yes
Legacy Posted Date
2014-05-09Usage metrics
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