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Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis

journal contribution
posted on 2023-06-08, 17:06 authored by Jemima C Stockton, Joanna M M Howson, Agnes A Awomoyi, Keith P McAdam, Jenefer M Blackwell, Melanie NewportMelanie Newport
The nucleotide oligomerization binding domain 2 gene (NOD2) encodes an intracellular receptor for bacterial components, which is expressed in monocytes and is associated with Crohn's Disease (CD). This finding, along with epidemiological evidence, supports a role for infection in the pathogenesis of CD. Speculation that mycobacteria are involved in CD led us to investigate NOD2 in susceptibility to tuberculosis (TB), a global public health problem caused by Mycobacterium tuberculosis. CD-associated NOD2 variants were absent in a case-control study of 640 Gambians, where CD is rare. Novel NOD2 promoter polymorphisms were identified but showed no association with TB in this African population sample.

History

Publication status

  • Published

Journal

FEMS Immunology and Medical Microbiology

ISSN

0928-8244

Publisher

Wiley

Issue

2

Volume

41

Page range

157-160

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-05-09

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