Stockton, Jemima C, Howson, Joanna M M, Awomoyi, Agnes A, McAdam, Keith P, Blackwell, Jenefer M and Newport, Melanie J (2004) Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis. FEMS Immunology and Medical Microbiology, 41 (2). pp. 157-160. ISSN 0928-8244
Full text not available from this repository.Abstract
The nucleotide oligomerization binding domain 2 gene (NOD2) encodes an intracellular receptor for bacterial components, which is expressed in monocytes and is associated with Crohn's Disease (CD). This finding, along with epidemiological evidence, supports a role for infection in the pathogenesis of CD. Speculation that mycobacteria are involved in CD led us to investigate NOD2 in susceptibility to tuberculosis (TB), a global public health problem caused by Mycobacterium tuberculosis. CD-associated NOD2 variants were absent in a case-control study of 640 Gambians, where CD is rare. Novel NOD2 promoter polymorphisms were identified but showed no association with TB in this African population sample.
Item Type: | Article |
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Schools and Departments: | Brighton and Sussex Medical School > Primary Care and Public Health Brighton and Sussex Medical School > Global Health and Infection |
Subjects: | R Medicine > RC Internal medicine > RC0251 Constitutional diseases (General) R Medicine > RC Internal medicine > RC0306 Tuberculosis |
Depositing User: | pam Thompson |
Date Deposited: | 09 May 2014 14:04 |
Last Modified: | 21 Sep 2017 13:34 |
URI: | http://srodev.sussex.ac.uk/id/eprint/48386 |