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Koch, Oliver, Awomoyi, Agnes, Usen, Stanley, Jallow, Muminatou, Richardson, Anna, Hull, Jeremy, Pinder, Margaret, Newport, Melanie and Kwiatkowski, Dominic (2002) IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. Journal of Infectious Diseases, 185 (11). pp. 1684-1687. ISSN 0022-1899
Full text not available from this repository.Abstract
Interferon (IFN)-gamma is a critical mediator of immunity to malaria. This study explored the relationship between polymorphisms in the promoter region of the gene encoding IFN-gamma receptor 1 (IFNGR1) and susceptibility to malaria in African children. Four polymorphisms were found in the region between -1400 and +100 nt of the translational start site by sequencing, and analysis of 562 nuclear families revealed 6 haplotypes. Case-control analysis of 562 Gambian children with severe malaria and 569 umbilical cord blood samples (controls) showed that in Mandinka, the major Gambian ethnic group, heterozygotes for the IFNGR1-56 polymorphism were protected against cerebral malaria (odds ratio, 0.54; P=.016) and against death resulting from cerebral malaria (odds ratio, 0.22; P=.006). Analysis of a family study by transmission disequilibrium testing revealed a similar result. Further data are needed to validate this finding, but these results are reminiscent of those for other well-established heterozygote advantages, such as that associated with hemoglobin S.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Primary Care and Public Health Brighton and Sussex Medical School > Global Health and Infection |
| Subjects: | R Medicine > RC Internal medicine > RC0251 Constitutional diseases (General) |
| Depositing User: | pam Thompson |
| Date Deposited: | 08 May 2014 17:15 |
| Last Modified: | 21 Sep 2017 13:39 |
| URI: | http://srodev.sussex.ac.uk/id/eprint/48397 |