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Performance_of_Tuberculin_Skin_Test_Measured_against_Interferon_Gamma_Release_Assay_as_Reference_Standard_in_Children..pdf (1.52 MB)

Performance of tuberculin skin test measured against interferon gamma release assay as reference standard in children

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posted on 2023-06-08, 17:20 authored by Michael Eisenhut, Katy FidlerKaty Fidler
Objectives. International guidelines differ in the threshold of tuberculin skin test (TST) induration regarded as indicating Mycobacterium (M.) tuberculosis infection. Interferon gamma release assay (IGRA) results were used as reference to assess performance of TST induration thresholds for detection of M. tuberculosis infection in children. Design. Systematic review which included studies containing data on TST, IGRA, and Bacillus Calmette-Gu´erin (BCG) status in children. Data bases searched were PubMed, EMBASE, and the Cochrane library. Specificities and sensitivities were calculated for TST thresholds 5, 10, and 15mm and correlated with age and geographical latitude. Results. Eleven studies with 2796 children were included. For BCG immunised children diameters of 5, 10, and 15mmhad median sensitivities of 87, 70, and 75%and specificities of 67, 93, and 90%, respectively. In non-BCG immunised children median sensitivities were 94, 95, and 83% and specificities 91, 95, and 97%. At the 10mm threshold age correlated negatively with sensitivity of TST (

History

Publication status

  • Published

File Version

  • Published version

Journal

Tuberculosis Research and Treatment

ISSN

2090-150X

Publisher

Hindawi Publishing Corporation

Volume

2014

Page range

413459

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2014-05-18

First Open Access (FOA) Date

2014-05-18

First Compliant Deposit (FCD) Date

2014-05-18

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