Inflammation and mental illness

Harrison, Neil (2013) Inflammation and mental illness. Journal of Neurology, Neurosurgery & Psychiatry, 84 (9). ISSN 0022-3050

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Dr Neil Harrison is a Consultant Neuropsychiatrist and Head of the Psychoneuroimmunology Lab at Brighton & Sussex Medical School. His research investigates how infection/ inflammation in the body interacts with the brain to modulate emotion, motivation and cognition and contribute to common mental illnesses such as depression, chronic fatigue and Alzheimer disease.

Once considered an immune privileged site, it is now clear that immune actions in the brain play a critical role in many fundamental neural processes and are increasingly implicated in the aetiology of mental illness. For example, cytokines, innate immune system proteins responsible for coordinating bodily responses to infection, are also critical to fundamental learning processes such as long term potentiation (LTP) in the brain. Microglial cells, the brains equivalent of macrophages, appear central to dendritic pruning and neural plasticity while MHC proteins central to self/non-self distinctions play a critical role in early neural development. Perhaps unsurprisingly given these roles aberrant immune responses are also increasingly implicated across the range of mental illnesses. In this talk I shall review mechanisms of immune modulation of neural function, summarise evidence implicating aberrant immune responses in common mental illnesses then finally present compelling new data demonstrating anti-depressant properties of a commonly used immuno-modulatory therapy. Together illustrating that psychoneuroimmunology has rapidly become an exciting new frontier for psychiatry.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
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Depositing User: Hazelle Woodhurst
Date Deposited: 05 Aug 2014 14:59
Last Modified: 03 Aug 2017 05:17

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