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Starting and stopping SUMOylation. What regulates the regulator?

journal contribution
posted on 2023-06-08, 18:02 authored by Felicity Watts
A large number of proteins are modified posttranslationally by the ubiquitin-like protein (Ubl) SUMO. This process, known as sumoylation, regulates the function, localisation and activity of target proteins as part of normal cellular metabolism, e.g., during development, and through the cell cycle, as well as in response to a range of stresses. In order to be effective, the sumoylation pathway itself must also be regulated. This review describes how the SUMOylation process is regulated. In particular, regulation of the SUMO conjugation and deconjugation machinery at the level of transcription and by post-translational modifications is discussed.

History

Publication status

  • Published

File Version

  • Published version

Journal

Chromosoma

ISSN

0009-5915

Publisher

Springer

Issue

6

Volume

122

Page range

451-463

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-08-07

First Compliant Deposit (FCD) Date

2014-08-07

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