Cross-diffusion-driven instability for reaction-diffusion systems: analysis and simulations

Madzvamuse, Anotida, Ndakwo, Hussaini S and Barreira, Raquel (2015) Cross-diffusion-driven instability for reaction-diffusion systems: analysis and simulations. Journal of Mathematical Biology, 70 (4). pp. 709-743. ISSN 0303-6812

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By introducing linear cross-diffusion for a two-component reaction-diffusion system with activator-depleted reaction kinetics (Gierer and Meinhardt, Kybernetik 12:30-39, 1972 ; Prigogine and Lefever, J Chem Phys 48:1695-1700, 1968 ; Schnakenberg, J Theor Biol 81:389-400, 1979), we derive cross-diffusion-driven instability conditions and show that they are a generalisation of the classical diffusion-driven instability conditions in the absence of cross-diffusion. Our most revealing result is that, in contrast to the classical reaction-diffusion systems without cross-diffusion, it is no longer necessary to enforce that one of the species diffuse much faster than the other. Furthermore, it is no longer necessary to have an activator-inhibitor mechanism as premises for pattern formation, activator-activator, inhibitor-inhibitor reaction kinetics as well as short-range inhibition and long-range activation all have the potential of giving rise to cross-diffusion-driven instability. To support our theoretical findings, we compute cross-diffusion induced parameter spaces and demonstrate similarities and differences to those obtained using standard reaction-diffusion theory. Finite element numerical simulations on planary square domains are presented to back-up theoretical predictions. For the numerical simulations presented, we choose parameter values from and outside the classical Turing diffusively-driven instability space; outside, these are chosen to belong to cross-diffusively-driven instability parameter spaces. Our numerical experiments validate our theoretical predictions that parameter spaces induced by cross-diffusion in both the (Formula presented.) and (Formula presented.) components of the reaction-diffusion system are substantially larger and different from those without cross-diffusion. Furthermore, the parameter spaces without cross-diffusion are sub-spaces of the cross-diffusion induced parameter spaces. Our results allow experimentalists to have a wider range of parameter spaces from which to select reaction kinetic parameter values that will give rise to spatial patterning in the presence of cross-diffusion.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Subjects: Q Science > QA Mathematics > QA0299 Analysis. Including analytical methods connected with physical problems
Depositing User: Anotida Madzvamuse
Date Deposited: 01 Sep 2014 08:40
Last Modified: 07 Mar 2017 04:20

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