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Association between serum trace element concentrations and the disease activity of systemic lupus erythematosus
journal contribution
posted on 2023-06-08, 18:16 authored by M Sahebari, M Abrishami-Moghaddam, A Moezzi, M Ghayour-Mobarhan, Z Mirfeizi, H Esmaily, Gordon FernsGordon FernsSystemic lupus erythematosus (SLE) is an autoimmune disease with a complex, incompletely understood, etiology. Several genetic and environmental factors are suspected to be involved in its aetiology. Oxidative stress may be implicated in the pathogenesis of SLE and may be affected by trace element status. Zinc (Zn), copper (Cu) and selenium (Se) are essential components of several anti-oxidative enzymes and are also involved in several immune functions. The current study aimed to assess the relationship between serum concentrations of these trace elements and the clinical disease activity of SLE assessed using the SLE disease activity index (SLEDAI). Serum concentrations of albumin (Alb) (p = 0.001), Se (p = 0.001), Zn (p = 0.001) and the Zn to Cu ratio (Zn/Cu R) (p = 0.001) were lower in patients with SLE than the age-and sex-matched healthy controls. However, only Alb (p = 0.001) and Cu (p = 0.03) were negatively correlated with disease activity, which was supported by regression analysis. In summary, lower serum values of Alb, Zn, Se and Zn/Cu R were found in SLE patients compared with healthy controls; however, in addition to serum Alb concentrations, serum Cu concentrations were also negatively correlated with lupus disease activity.
History
Publication status
- Published
Journal
LupusISSN
0961-2033Publisher
Arnold PublishersExternal DOI
Issue
8Volume
23Page range
793-801Department affiliated with
- Division of Medical Education Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-09-12Usage metrics
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