Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups

Amin, Jahangir, Chuckowree, Irina, Wang, Minghua, Tizzard, Graham J, Coles, Simon J and Spencer, John (2013) Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups. Organometallics, 32 (20). pp. 5818-5825. ISSN 0276-7333

Full text not available from this repository.

Abstract

A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science
Depositing User: Deeptima Massey
Date Deposited: 30 Sep 2014 11:10
Last Modified: 30 Sep 2014 11:10
URI: http://srodev.sussex.ac.uk/id/eprint/50418
📧 Request an update