Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors

Amin, Jahangir, Chuckowree, Irina, Tizzard, Graham J, Coles, Simon J, Wang, Minghua, Bingham, John P, Hartley, John A and Spencer, John (2013) Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors. Organometallics, 32 (2). pp. 509-513. ISSN 0276-7333

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Abstract

A series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticancer activity, against epidermal growth receptor (EGFR), and submicromolar IC50 values have been determined.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science
Depositing User: Deeptima Massey
Date Deposited: 30 Sep 2014 11:29
Last Modified: 02 Oct 2014 14:59
URI: http://srodev.sussex.ac.uk/id/eprint/50420
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