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Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors
journal contribution
posted on 2023-06-08, 18:32 authored by Jahangir Amin, Irina Chuckowree, Graham J Tizzard, Simon J Coles, Minghua Wang, John P Bingham, John A Hartley, John SpencerJohn SpencerA series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticancer activity, against epidermal growth receptor (EGFR), and submicromolar IC50 values have been determined.
History
Publication status
- Published
Journal
OrganometallicsISSN
0276-7333Publisher
American Chemical SocietyExternal DOI
Issue
2Volume
32Page range
509-513Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-09-30Usage metrics
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