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Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors

journal contribution
posted on 2023-06-08, 18:32 authored by Jahangir Amin, Irina Chuckowree, Graham J Tizzard, Simon J Coles, Minghua Wang, John P Bingham, John A Hartley, John SpencerJohn Spencer
A series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticancer activity, against epidermal growth receptor (EGFR), and submicromolar IC50 values have been determined.

History

Publication status

  • Published

Journal

Organometallics

ISSN

0276-7333

Publisher

American Chemical Society

Issue

2

Volume

32

Page range

509-513

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-09-30

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