File(s) not publicly available
Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation
journal contribution
posted on 2023-06-08, 18:34 authored by Valentina Oliveri, Francesco Attanasio, Attanasio Puglisi, John SpencerJohn Spencer, Carmelo Sgarlata, Graziella VecchioMounting evidence suggests a pivotal role of metal imbalances in protein misfolding and amyloid diseases. As such, metal ions represent a promising therapeutic target. In this context, the synthesis of chelators that also contain complementary functionalities to combat the multifactorial nature of neurodegenerative diseases is a highly topical issue. We report two new 8-hydroxyquinoline-appended cyclodextrins and highlight their multifunctional properties, including their CuII and ZnII binding abilities, and capacity to act as antioxidants and metal-induced antiaggregants. In particular, the latter property has been applied in the development of an effective assay that exploits the formation of amyloid fibrils when b-lactoglobulin A is heated in the presence of metal ions.
History
Publication status
- Published
Journal
Chemistry - A European JournalISSN
0947-6539Publisher
Wiley-VCH Verlag BerlinExternal DOI
Issue
29Volume
20Page range
8954-8964Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-09-30Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC