Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation

Oliveri, Valentina, Attanasio, Francesco, Puglisi, Attanasio, Spencer, John, Sgarlata, Carmelo and Vecchio, Graziella (2014) Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation. Chemistry - A European Journal, 20 (29). pp. 8954-8964. ISSN 0947-6539

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Abstract

Mounting evidence suggests a pivotal role of metal imbalances in protein misfolding and amyloid diseases.

As such, metal ions represent a promising therapeutic
target. In this context, the synthesis of chelators that also contain complementary functionalities to combat the multifactorial nature of neurodegenerative diseases is a highly topical issue. We report two new 8-hydroxyquinoline-appended cyclodextrins and highlight their multifunctional
properties, including their CuII and ZnII binding abilities, and capacity to act as antioxidants and metal-induced antiaggregants.

In particular, the latter property has been applied in
the development of an effective assay that exploits the formation of amyloid fibrils when b-lactoglobulin A is heated in the presence of metal ions.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science
Depositing User: Deeptima Massey
Date Deposited: 30 Sep 2014 14:26
Last Modified: 11 May 2015 11:08
URI: http://srodev.sussex.ac.uk/id/eprint/50449
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