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An investigation of physicochemical properties of piroxicam liquisolid compacts

journal contribution
posted on 2023-06-08, 19:18 authored by Yousef Javadzadeh, Mohammad Reza Siahi, Solmaz Asnaashari, Ali Nokhodchi
The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (piroxicam) was investigated. In this study, physicochemical properties of piroxicam liquisolid tablets, effect of aging, and type of the carrier were also investigated. To this end, several liquisolid tablets formulations containing various ratios of drug: solvent and different carriers were prepared. X-ray crystallography, differential scanning calorimetry (DSC), and contact angle measurement were used for evaluation of physicochemical properties of piroxicam. Liquisolid compacts exhibited significantly higher drug dissolution rates, in different dissolution media, than compacts prepared by the direct compression technique. The results showed that enhanced dissolution rate of piroxicam liquisolid tablets was due to an increase in wetting properties and surface area of drug available for dissolution. To investigate the effect of aging on the hardness and dissolution rate of liquisolid compacts, the formulations were stored at 25°C/75% relative humidity for 9 months. The results showed that aging had no significant effect on hardness or dissolution profile of liquisolid tablets. It was shown that Avicel had more liquid retention potential than other carriers, but there were no significant differences in the dissolution profiles between formulations. The results of DSC and X-ray crystallography did not show any changes in crystallinity of the drug and interaction between piroxicam and exipients (Avicel and silica) during the process.

History

Publication status

  • Published

Journal

Pharmaceutical Development and Technology

ISSN

1083-7450

Publisher

Taylor & Francis

Issue

3

Volume

12

Page range

337-343

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-07

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