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A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption

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posted on 2023-06-08, 19:20 authored by Mohammad Barzegar-Jalali, Kaivan Mohammadi, Ghobad Mohammadi, Hadi Valizadeh, Azim Barzegar-Jalali, Khosro Adibkia, Ali Nokhodchi
Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo. Methods. A novel in vitro in vivo correlation, IVIVC, model denoted as double reciprocal area method was presented and applied to 19 drugs from 55 nano formulations with total 336 data, gathered from literature. Results. The proposed model correlated the in vitro with in vivo parameters with overall error of 12.4 ± 3.9%. Also the trained version of the model predicted the test formulations with overall error of 15.8 ± 3.7% indicating the suitability of the approach. A theoretical justification was provided for the model considering the unified classical release laws. Conclusion. The model does not necessitate bolus intravenous drug data and seems to be suitable for IVIVC of drugs with release rate-limited absorption.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Pharmacy and Pharmaceutical Sciences

ISSN

1482-1826

Publisher

Canadian Society for Pharmaceutical Sciences

Issue

4

Volume

15

Page range

583-591

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2014-12-18

First Open Access (FOA) Date

2014-12-18

First Compliant Deposit (FCD) Date

2014-12-18

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