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Barzegar-Jalali_et_al_(2008).pdf (160.93 kB)

Kinetic analysis of drug release from nanoparticles

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journal contribution
posted on 2023-06-08, 19:25 authored by Mohammad Barzegar-Jalali, Khosro Adibkia, Hadi Valizadeh, Mohammad Reza Siahi Shadbad, Ali Nokhodchi, Yadollah Omidi, Ghobad Mohammadi, Somayeh Hallaj Nezhadi, Maryam Hasan
PURPOSE. Comparative drug release kinetics from nanoparticles was carried out using conventional and our novel models with the aim of finding a general model applicable to multi mechanistic release. Theoretical justification for the two best general models was also provided for the first time. METHODS. Ten conventional models and three models developed in our laboratory were applied to release data of 32 drugs from 106 nanoparticle formulations collected from literature. The accuracy of the models was assessed employing mean percent error (E) of each data set, overall mean percent error (OE) and number of Es less than 10 percent. RESULTS. Among the models the novel reciprocal powered time (RPT), Weibull (W) and log-probability (LP) ones produced OE values of 6.47, 6.39 and 6.77, respectively. The OEs of other models were higher than 10%. Also the number of errors less than 10% for the models was 84.9, 80.2 and 78.3 percents of total number of data sets. CONCLUSIONS. Considering the accuracy criteria the reciprocal powered time model could be suggested as a general model for analysis of multi mechanistic drug release from nanoparticles. Also W and LP models were the closest to the suggested model RPT.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Pharmacy and Pharmaceutical Sciences

ISSN

1482-1826

Publisher

Canadian Society for Pharmaceutical Sciences

Issue

1

Volume

11

Page range

167-177

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-05

First Open Access (FOA) Date

2015-01-05

First Compliant Deposit (FCD) Date

2015-01-05

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