Converging evidence for central 5-HT effects in acute tryptophan depletion

Crockett, M J, Clark, L, Roiser, J P, Robinson, O J, Cools, R, Chase, H W, Ouden, H den, Apergis-Schoute, A, Campbell-Meikeljohn, D, Seymour, B, Sahakian, B J, Rogers, R D and Robbins, T W (2012) Converging evidence for central 5-HT effects in acute tryptophan depletion. Molecular Psychiatry, 17 (2). pp. 121-123. ISSN 1359-4184

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Acute tryptophan depletion (ATD), a dietary technique for manipulating brain serotonin (5-HT) function, has advanced our understanding of 5-HT mechanisms in the etiology and treatment of depression and other affective disorders.1 A recent review article in Molecular Psychiatry questioned the validity of ATD.2 Although we agree that ATD's effects on 5-HT activity at the molecular level need further clarification, van Donkelaar et al.2 goes too far in challenging whether ATD exerts its effects through serotonergic mechanisms. There is strong evidence that ATD reduces brain 5-HT and disrupts stimulated 5-HT release,3, 4 and converging translational findings support a central role for brain 5-HT in ATD's effects on cognition and behavior.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology
Depositing User: Daniel Campbell-Meiklejohn
Date Deposited: 11 Feb 2016 10:22
Last Modified: 11 Feb 2016 10:22
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