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Conditioned taste aversion: modulation by 5-HT receptor activity and corticosterone

journal contribution
posted on 2023-06-08, 19:28 authored by Boris Gorzalka, Laura Hanson, Jennifer Harrington, Sisley Killam, Dan Campbell-MeiklejohnDan Campbell-Meiklejohn
Two experiments were designed to elucidate the involvement of the hypothalamic-pituitary-adrenal axis and the 5-hydroxytryptamine (5-HT) system in the acquisition of lithium chloride-conditioned taste aversion. In Experiment 1, rats were administered either vehicle or 50 mg/kg nefazodone daily for 4 weeks. Rats were treated with 22 mg/kg of lithium chloride in order to produce conditioned taste aversion to a sucrose solution. Three days later, nefazodone completely blocked the lithium chloride-conditioned taste aversion. In Experiment 2, the effects of chronic corticosterone administration on lithium chloride-conditioned taste aversion were investigated. Twenty male rats received either corticosterone at a dose of (50 mg/kg) or vehicle injections over a period of 14 consecutive days. Lithium chloride-conditioned taste aversion was potentiated in rats treated with corticosterone. Additionally, corticosterone-treated animals required more trials to reach extinction. These results suggest the involvement of both the 5-HT system and the hypothalamic-pituitary-adrenal axis in lithium chloride-conditioned taste aversion.

History

Publication status

  • Published

Journal

European Journal of Pharmacology

ISSN

0014-2999

Publisher

Elsevier

Issue

2

Volume

471

Page range

129-134

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-02-11

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