Conditioned taste aversion: modulation by 5-HT receptor activity and corticosterone

Gorzalka, Boris, Hanson, Laura, Harrington, Jennifer, Killam, Sisley and Campbell-Meiklejohn, Dan (2003) Conditioned taste aversion: modulation by 5-HT receptor activity and corticosterone. European Journal of Pharmacology, 471 (2). pp. 129-134. ISSN 0014-2999

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Two experiments were designed to elucidate the involvement of the hypothalamic-pituitary-adrenal axis and the 5-hydroxytryptamine (5-HT) system in the acquisition of lithium chloride-conditioned taste aversion. In Experiment 1, rats were administered either vehicle or 50 mg/kg nefazodone daily for 4 weeks. Rats were treated with 22 mg/kg of lithium chloride in order to produce conditioned taste aversion to a sucrose solution. Three days later, nefazodone completely blocked the lithium chloride-conditioned taste aversion. In Experiment 2, the effects of chronic corticosterone administration on lithium chloride-conditioned taste aversion were investigated. Twenty male rats received either corticosterone at a dose of (50 mg/kg) or vehicle injections over a period of 14 consecutive days. Lithium chloride-conditioned taste aversion was potentiated in rats treated with corticosterone. Additionally, corticosterone-treated animals required more trials to reach extinction. These results suggest the involvement of both the 5-HT system and the hypothalamic-pituitary-adrenal axis in lithium chloride-conditioned taste aversion.

Item Type: Article
Keywords: conditioned taste aversion, lithium, learning, serotonin, cortisol
Schools and Departments: School of Psychology > Psychology
Subjects: Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology
Depositing User: Daniel Campbell-Meiklejohn
Date Deposited: 11 Feb 2016 10:03
Last Modified: 11 Feb 2016 10:03
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