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Identification of novel IP receptor agonists using historical ligand biased chemical arrays

journal contribution
posted on 2023-06-08, 19:29 authored by Stephen C McKeown, Steven J Charlton, Brian Cox, Helen Fitch, Christopher D Howson, Catherine Leblanc, Arndt Meyer, Elizabeth M Rosethorne, Emily Stanley
By considering published structural information we have designed high throughput biaryl lipophilic acid arrays leveraging facile chemistry to expedite their synthesis. We rapidly identified multiple hits which were of suitable IP agonist potency. These relatively simple and strategically undecorated molecules present an ideal opportunity for optimization towards our target candidate profile.

History

Publication status

  • Published

Journal

Bioorganic and Medicinal Chemistry Letters

ISSN

0960-894X

Publisher

Elsevier

Issue

10

Volume

24

Page range

2247-2250

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-12

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