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Neural networks supporting autobiographical memory retrieval in posttraumatic stress disorder
journal contribution
posted on 2023-06-08, 19:38 authored by Peggy L St Jacques, Philip A Kragel, David C RubinPosttraumatic stress disorder (PTSD) affects the functional recruitment and connectivity between neural regions during autobiographical memory (AM) retrieval that overlap with default and control networks. Whether such univariate changes relate to potential differences in the contributions of the large-scale neural networks supporting cognition in PTSD is unknown. In the present functional MRI study, we employed independent-component analysis to examine the influence of the engagement of neural networks during the recall of personal memories in a PTSD group (15 participants) as compared to non-trauma-exposed healthy controls (14 participants). We found that the PTSD group recruited similar neural networks when compared to the controls during AM recall, including default-network subsystems and control networks, but group differences emerged in the spatial and temporal characteristics of these networks. First, we found spatial differences in the contributions of the anterior and posterior midline across the networks, and of the amygdala in particular, for the medial temporal subsystem of the default network. Second, we found temporal differences within the medial prefrontal subsystem of the default network, with less temporal coupling of this network during AM retrieval in PTSD relative to controls. These findings suggest that the spatial and temporal characteristics of the default and control networks potentially differ in a PTSD group versus healthy controls and contribute to altered recall of personal memory.
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Publication status
- Published
File Version
- Published version
Journal
Cognitive, Affective, and Behavioral NeuroscienceISSN
1530-7026Publisher
Springer VerlagExternal DOI
Issue
3Volume
13Page range
554-566Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-01-21First Compliant Deposit (FCD) Date
2015-01-22Usage metrics
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