TRP channels in airway smooth muscle as therapeutic targets

Gosling, Martin, Poll, Chris and Li, Su (2005) TRP channels in airway smooth muscle as therapeutic targets. Naunyn-Schmiedeberg's Archives of Pharmacology, 371 (4). pp. 277-284. ISSN 0028-1298

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Abstract

Cation channels are of fundamental importance in regulating the function of airway smooth cells especially bronchoconstriction in response to spasmogens, and are therefore key players in the pathogenesis of asthma. To date, the identity of these cation channels remains a mystery. However, the recently emerged transient receptor potential (TRP) cation channel family has provided several promising channel candidates. The identification of the key TRP channels involved in regulating airway smooth muscle contractility, and therefore airway tone, could provide new and exciting prospects for the development of novel therapies for the treatment of airway diseases such as asthma. © Springer-Verlag 2005.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 26 Jan 2015 13:46
Last Modified: 26 Jan 2015 13:46
URI: http://srodev.sussex.ac.uk/id/eprint/52466
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