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The trafficking and targeting of P2X receptors

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posted on 2023-06-08, 19:51 authored by Lucy E Robinson, Ruth Murrell-LagnadoRuth Murrell-Lagnado
The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very different trafficking properties. Some are retained within the endoplasmic reticulum (ER), while others are predominantly at the cell surface or within endosomes and lysosomes. Changes in recruitment of receptors to and from the plasma membrane provides a way of rapidly up- or down-regulating the cellular response to adenosine triphosphate (ATP). An additional layer of regulation is the targeting of these receptors within the membranes of each compartment, which affects their stability, function and the nature of the effector proteins with which they form signaling complexes. The trafficking and targeting of P2X receptors is regulated by their interactions with other proteins and with lipids and we can expect this to vary in a cell-type specific manner and in response to changes in the environment giving rise to differences in receptor activity and function.

History

Publication status

  • Published

File Version

  • Published version

Journal

Frontiers in Cellular Neuroscience

ISSN

1662-5102

Publisher

Frontiers

Volume

7

Page range

233

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2015-03-25

First Open Access (FOA) Date

2015-03-25

First Compliant Deposit (FCD) Date

2015-03-25

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