Modulation of the feeding response to peripheral insulin, 2-deoxyglucose or 3-0-methyl glucose injection

The effects of circadian rhythm, delayed access to food, bilateral subdiaphragmatic vagotomy and bilateral adrenal medullectomy were examined. Like normal insulin injected subcutaneously, 2-deoxy-D-glucose injected intraperitoneally induces feeding in sated rats by night as well as by day. The unmetabolized glucose analogue 3-O-methyl-D-glucopyranose detectably increases feeding by day. On delayed return of food after 2-deoxyglucose injection into mildly deprived rats, feeding is at first inhibited and then facilitated. Vagotomy but not medullectomy interferes with 2-deoxyglucose-induced feeding, whereas medullectomy but not vagotomy interferes with insulin-induced feeding, when dosages near the optima for intact rats are used. However, when low doses are given, neither surgically induced deficit is evident.