Aryloxypyrazines as highly selective antagonists of Oxytocin

Brown, Alan, Ellis, Dave, Pearce, David, Ralph, Michael and Sciammetta, Nunzio (2009) Aryloxypyrazines as highly selective antagonists of Oxytocin. Bioorganic and Medicinal Chemistry Letters, 19 (10). pp. 2634-2636. ISSN 0960-894X

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A series of aryloxypyrazines were designed based on structural overlap with previously reported arylpyrazine Oxytocin antagonists. Similarly high levels of Oxytocin antagonism were achievable in this new series. In addition, significant improvements in selectivity over the related vasopressin V1A receptor were also possible.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 01 Jun 2015 10:21
Last Modified: 01 Jun 2015 10:21
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