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Genetic and epigenetic studies of amyotrophic lateral sclerosis
journal contribution
posted on 2023-06-08, 20:55 authored by Ammar Al-Chalabi, Shin Kwak, Mark Mehler, Guy Rouleau, Teepu Siddique, Michael Strong, Nigel LeighNigel LeighThe identification of genetic and epigenetic factors that are associated with an increased risk of developing amyotrophic lateral sclerosis (ALS), or that modify the age of onset or rate of progression, requires a multimodal research strategy, facilitated through international collaboration. The discovery of several ALS genes strongly linked to RNA biology, the proteasome pathway, and axonal transport suggest they have an important role in pathogenesis, but the immense complexity of these processes is also apparent. The increasing rate of genetic discoveries brings the hope of designing more targeted and efficacious therapies.
History
Publication status
- Published
Journal
Amyotrophic Lateral Sclerosis and Frontotemporal DegenerationISSN
2167-9223Publisher
Informa HealthcareExternal DOI
Issue
S1Volume
14Page range
44-52Department affiliated with
- BSMS Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-06-01Usage metrics
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